Mastelli

Newest – Skin Booster with Polynucleotides, Hyaluronic Acid & Mannitol Newest is an advanced skin booster from Mastelli Aesthetics, formulated to regenerate and revitalize mature, dehydrated, or structurally compromised skin. Its highly effective formula combines non‑crosslinked hyaluronic acid, highly purified polynucleotides (PN‑HPT®), and mannitol to improve skin structure, stimulate cellular regeneration, and deliver long‑lasting hydration. Newest is ideal for treating the face, neck, décolletage, and hands—particularly for early signs of aging, scarring, and volume depletion. Composition 20 mg/2 ml polynucleotides (PN‑HPT®) 20 mg/2 ml hyaluronic acid (non‑crosslinked) Mannitol Indications Newest is indicated for bio‑revitalizing treatment of: Mature and dehydrated skin Mid‑face region Atrophic scars and acne scars Face, neck, décolletage, and hands Application Newest is injected intradermally into the dermis. Various injection techniques may be used to ensure even product distribution. A recommended initial treatment cycle consists of 3 sessions spaced 14 to 21 days apart. For maintenance, treatments may be repeated every 3 to 6 months. Newest can be used as a standalone therapy or as preparation for aesthetic or surgical procedures. Duration of Effect Results are often visible within a few weeks and typically last 4 to 6 months, depending on skin type, age, lifestyle, and treatment protocol. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Newest One – Skin Revitalization with Polynucleotides & Hyaluronic Acid Newest One is an advanced skin revitalization product from Mastelli, specially developed for the treatment of large body areas. Its unique combination of highly purified polynucleotides (PN‑HPT®) and non‑crosslinked hyaluronic acid promotes deep cellular regeneration, improves overall skin structure, and helps restore firmness, elasticity, and hydration. Newest One is particularly suitable for patients with sagging, dull, or structurally damaged skin, as well as for those dealing with scars, stretch marks, or volume loss. Composition 1 mg/ml polynucleotides (PN‑HPT®) 1 mg/ml hyaluronic acid (non‑crosslinked) Mannitol Indications Newest One is indicated for the treatment of: Mature, dehydrated, or photo‑damaged skin Atrophic scars and stretch marks Volume loss and skin laxity Large areas such as the abdomen, buttocks, thighs, arms, and décolletage Application Newest One is administered intradermally into the dermis. It can be applied using standard injection techniques or through non‑invasive approaches such as iontophoresis, electroporation, or hydroelectrophoresis. For optimal results, a treatment cycle of 3 to 4 sessions, spaced 14 to 21 days apart, is recommended. Maintenance treatments may be performed every 3 to 6 months to preserve long‑term improvements. Duration of Effect The results typically last 4 to 6 months, depending on skin type, age, lifestyle, and technique used. Initial visible improvements often appear after the second treatment session. Packaging Content 5 glass ampoules × 4 ml No needles included (manufacturer recommends a 30G needle) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

NewGyn® – Intimate Regeneration with Polynucleotides & Hyaluronic Acid NewGyn® is an innovative injectable product from Mastelli, specifically developed for the regeneration and revitalization of the female intimate area. Its unique combination of highly purified polynucleotides (PN‑HPT®) and non‑crosslinked hyaluronic acid provides intensive hydration, improves tissue elasticity, and supports natural cellular regeneration. NewGyn® is particularly suitable for addressing dryness, irritation, age‑ or hormone‑related atrophy, and for aiding recovery following gynecological procedures. Its gentle yet effective formulation helps restore comfort, softness, and physiological balance in delicate intimate tissues. Composition 10 mg/2 ml polynucleotides (PN‑HPT®) 10 mg/2 ml hyaluronic acid (non‑crosslinked) Mannitol Indications NewGyn® is indicated for rehydration, firming, and restoring the physiological condition of the superficial skin and mucosal layers in the female genital area. It is suitable for treating: Vaginal and vulvar dryness Irritation Itching Dyspareunia Tissue atrophy Post‑gynecological procedure recovery Application NewGyn® is administered minimally invasively into the dermis or superficial mucosal tissue. Treatment is performed directly in the vulvo‑vaginal area using the micropomfi technique and retrograde linear injection for even distribution of the active ingredients. An initial treatment cycle of 3 to 4 sessions, spaced 7 to 14 days apart, is recommended to achieve optimal results. Maintenance treatments can be tailored to individual needs and repeated regularly as required. Duration of Effect Results are often noticeable after the first session. The benefits typically last 6 to 12 months, depending on the patient’s skin type, age, and hormonal balance. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½") Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest – Biostimulating Gel for Skin Structure Improvement with Polynucleotides Plinest is an innovative biostimulating gel based on highly purified polynucleotides (PN‑HPT®), specifically formulated to support targeted skin regeneration and structural improvement. Developed in Italy, Plinest utilizes the restorative power of DNA fragments to activate cellular repair processes, enhance skin elasticity, and promote a healthy moisture balance. It is highly effective for treating mature, stressed, or scarred skin—all without hormonal additives. The result is a visibly smoother, firmer, and more radiant complexion. Composition Polynucleotides (PN‑HPT®): 40 mg/2 ml (equivalent to 20 mg/ml) Indications Plinest is suitable for the treatment of: Skin rejuvenation in cases of elasticity loss Photo‑damaged skin Improvement of acne scars and other scars Restructuring dry or dehydrated skin Optimization of skin texture and firmness Application The product is injected intradermally into the mid to deep dermis. A typical treatment protocol consists of 3 to 4 sessions spaced 2 to 3 weeks apart. Maintenance treatments can be performed every 4 to 6 months, depending on the patient’s skin condition and desired outcome. Duration of Effect Results generally last 6 to 9 months, depending on the individual’s skin condition, lifestyle, and biological response. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½'', 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest Eye – Gentle Skin Revitalization for the Delicate Under‑Eye Area Plinest Eye is a specialized injectable gel designed to regenerate and rejuvenate the sensitive skin around the eyes. Utilizing proven PN‑HPT® technology with highly purified polynucleotides, it stimulates cell renewal, improves skin structure, and provides deep hydration without the use of hormonal or artificial active ingredients. It is ideal for treating fine lines, dark circles, mild puffiness, and overall structural damage in the periorbital region, resulting in a brighter, smoother, and more refreshed appearance. Composition Polynucleotides (PN‑HPT®): 15 mg/2 ml (equivalent to 7.5 mg/ml) Indications Plinest Eye is suitable for: Fine lines and superficial wrinkles Crow’s feet Dark circles and mild under‑eye swelling Upper eyelid skin laxity Structurally damaged skin around the eyes Uneven tone and texture in the periorbital area Application Plinest Eye is injected intradermally in small amounts into the dermis. The recommended initial protocol includes 3 to 4 treatment sessions spaced 2 to 3 weeks apart. Maintenance treatments may be repeated regularly depending on skin condition and patient needs. Its gentle formulation makes it suitable for delicate, thin periorbital skin. Duration of Effect Results typically last 6 to 12 months, varying with skin type, age, lifestyle, and the patient’s natural regenerative capacity. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest Fast – Rapid Skin Regeneration with Highly Purified Polynucleotides Plinest Fast is an innovative injectable gel designed for targeted regeneration and revitalization of damaged skin. Powered by patented PN‑HPT® technology, it delivers highly purified polynucleotides that stimulate cell renewal, improve overall skin structure, and activate natural healing processes. Particularly suitable for treating scars and stretch marks, Plinest Fast offers an effective solution for patients with skin in need of accelerated repair and reinforcement. Composition Polynucleotides (PN‑HPT®): 15 mg/2 ml (equivalent to 7.5 mg/ml) Indications Plinest Fast is suitable for: Stretch marks Acne and surgical scars Structurally damaged skin following aesthetic procedures Fine lines and dehydration wrinkles Mature, sensitive, or dehydrated skin Application Plinest Fast is injected intradermally into the mid‑dermal layer. A recommended initial protocol includes 3 to 4 sessions, spaced 10 to 14 days apart. For maintenance, treatments may be repeated every 4 to 6 weeks. After each session, patients should avoid intense sun exposure, sauna use, steam baths, and physical exercise for at least 24 hours. Duration of Effect Results typically last 4 to 6 months, depending on individual skin type, lifestyle, and overall skin condition. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest Hair – Biological Support for Hair Growth & Scalp Regeneration Plinest Hair is an innovative injectable gel designed to revitalize the scalp and support healthy hair growth. Powered by patented PN‑HPT® technology, it delivers highly purified polynucleotides that activate cellular regeneration, improve microcirculation, and strengthen the environment surrounding hair follicles. Suitable for both men and women with sensitive or weakened scalp conditions, Plinest Hair can also be used as an adjunct treatment before or after hair transplantation procedures to enhance overall follicular support. Composition Polynucleotides (PN‑HPT®): 15 mg/2 ml (equivalent to 7.5 mg/ml) Indications Plinest Hair is suitable for: Hair loss Weak or compromised hair follicles Scalp revitalization Stimulation of hair growth Enhancing eyebrow density Application Plinest Hair is injected intradermally into the scalp or eyebrow region. A recommended initial treatment cycle consists of 4 to 6 sessions, spaced 7 days apart. For maintenance, treatment may be repeated every 4 to 6 weeks. After application, patients should avoid intense sun exposure, sauna use, steam baths, and vigorous physical activity for 24 hours to ensure optimal results. Duration of Effect Results typically last 6 to 12 months, depending on individual factors such as hair structure, skin type, lifestyle, and overall scalp health. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest One – Deep‑Acting Skin Revitalization for Large Body Areas Plinest One is an advanced biostimulation gel based on highly purified polynucleotides (PN‑HPT®), specifically developed for the treatment and restructuring of large skin areas. The formulation visibly improves firmness, elasticity, and overall skin texture, making it ideal for patients experiencing skin laxity, stretch marks, or age‑related structural deterioration on the abdomen, buttocks, thighs, arms, and décolletage. Composition Polynucleotides (PN‑HPT®): 2 mg/ml Indications Plinest One is suitable for improving: Skin laxity on arms, thighs, abdomen, and buttocks Loss of elasticity in the décolletage Visible stretch marks (e.g., post‑pregnancy or after weight loss) Skin texture, firmness, and hydration Application Plinest One is injected intradermally into the mid dermal layer. For optimal results, the manufacturer recommends a treatment course of 3 to 6 sessions, spaced 2 to 4 weeks apart. As an alternative to injection, it may also be applied using non‑invasive methods such as iontophoresis, electroporation, or hydroelectrophoresis, depending on practitioner preference and patient suitability. Duration of Effect Results typically last 6 to 12 months, depending on individual skin condition, lifestyle, and physiological factors. Packaging Content 5 glass ampoules × 4 ml No needles included (manufacturer recommends 30G) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.