PDRN Fillers – Advanced Skin Regeneration & Rejuvenation

Newest – Skin Booster with Polynucleotides, Hyaluronic Acid & Mannitol Newest is an advanced skin booster from Mastelli Aesthetics, formulated to regenerate and revitalize mature, dehydrated, or structurally compromised skin. Its highly effective formula combines non‑crosslinked hyaluronic acid, highly purified polynucleotides (PN‑HPT®), and mannitol to improve skin structure, stimulate cellular regeneration, and deliver long‑lasting hydration. Newest is ideal for treating the face, neck, décolletage, and hands—particularly for early signs of aging, scarring, and volume depletion. Composition 20 mg/2 ml polynucleotides (PN‑HPT®) 20 mg/2 ml hyaluronic acid (non‑crosslinked) Mannitol Indications Newest is indicated for bio‑revitalizing treatment of: Mature and dehydrated skin Mid‑face region Atrophic scars and acne scars Face, neck, décolletage, and hands Application Newest is injected intradermally into the dermis. Various injection techniques may be used to ensure even product distribution. A recommended initial treatment cycle consists of 3 sessions spaced 14 to 21 days apart. For maintenance, treatments may be repeated every 3 to 6 months. Newest can be used as a standalone therapy or as preparation for aesthetic or surgical procedures. Duration of Effect Results are often visible within a few weeks and typically last 4 to 6 months, depending on skin type, age, lifestyle, and treatment protocol. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Newest One – Skin Revitalization with Polynucleotides & Hyaluronic Acid Newest One is an advanced skin revitalization product from Mastelli, specially developed for the treatment of large body areas. Its unique combination of highly purified polynucleotides (PN‑HPT®) and non‑crosslinked hyaluronic acid promotes deep cellular regeneration, improves overall skin structure, and helps restore firmness, elasticity, and hydration. Newest One is particularly suitable for patients with sagging, dull, or structurally damaged skin, as well as for those dealing with scars, stretch marks, or volume loss. Composition 1 mg/ml polynucleotides (PN‑HPT®) 1 mg/ml hyaluronic acid (non‑crosslinked) Mannitol Indications Newest One is indicated for the treatment of: Mature, dehydrated, or photo‑damaged skin Atrophic scars and stretch marks Volume loss and skin laxity Large areas such as the abdomen, buttocks, thighs, arms, and décolletage Application Newest One is administered intradermally into the dermis. It can be applied using standard injection techniques or through non‑invasive approaches such as iontophoresis, electroporation, or hydroelectrophoresis. For optimal results, a treatment cycle of 3 to 4 sessions, spaced 14 to 21 days apart, is recommended. Maintenance treatments may be performed every 3 to 6 months to preserve long‑term improvements. Duration of Effect The results typically last 4 to 6 months, depending on skin type, age, lifestyle, and technique used. Initial visible improvements often appear after the second treatment session. Packaging Content 5 glass ampoules × 4 ml No needles included (manufacturer recommends a 30G needle) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

NewGyn® – Intimate Regeneration with Polynucleotides & Hyaluronic Acid NewGyn® is an innovative injectable product from Mastelli, specifically developed for the regeneration and revitalization of the female intimate area. Its unique combination of highly purified polynucleotides (PN‑HPT®) and non‑crosslinked hyaluronic acid provides intensive hydration, improves tissue elasticity, and supports natural cellular regeneration. NewGyn® is particularly suitable for addressing dryness, irritation, age‑ or hormone‑related atrophy, and for aiding recovery following gynecological procedures. Its gentle yet effective formulation helps restore comfort, softness, and physiological balance in delicate intimate tissues. Composition 10 mg/2 ml polynucleotides (PN‑HPT®) 10 mg/2 ml hyaluronic acid (non‑crosslinked) Mannitol Indications NewGyn® is indicated for rehydration, firming, and restoring the physiological condition of the superficial skin and mucosal layers in the female genital area. It is suitable for treating: Vaginal and vulvar dryness Irritation Itching Dyspareunia Tissue atrophy Post‑gynecological procedure recovery Application NewGyn® is administered minimally invasively into the dermis or superficial mucosal tissue. Treatment is performed directly in the vulvo‑vaginal area using the micropomfi technique and retrograde linear injection for even distribution of the active ingredients. An initial treatment cycle of 3 to 4 sessions, spaced 7 to 14 days apart, is recommended to achieve optimal results. Maintenance treatments can be tailored to individual needs and repeated regularly as required. Duration of Effect Results are often noticeable after the first session. The benefits typically last 6 to 12 months, depending on the patient’s skin type, age, and hormonal balance. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½") Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

NucleoFill™ Medium – Bio-Revitalizing Gel with Polynucleotides 1.5 mlNucleoFill™ Medium is an innovative bio-revitalizing gel based on polymerized polynucleotides, designed to rejuvenate the skin, reduce wrinkles, and improve the appearance of scars and stretch marks. It stimulates cell regeneration and activates fibroblasts, resulting in improved skin structure and visible firming, even in tired or sagging skin. Suitable for treatment of the face, neck, décolleté, hands, thighs, and buttocks. Composition: Polynucleotides: 20 mg/ml Pre-filled syringe: 1.5 ml Indications: Mild to moderate wrinkles (e.g., perioral lines, fine cheek wrinkles) Medium scars Stretch marks on thighs and buttocks Sagging skin on face, neck, décolleté, hands, thighs, and buttocks Deep hydration and antioxidant protection for dry or oxidatively stressed skin Application: NucleoFill™ Medium is administered intradermally via mesotherapy to achieve optimal bio-restructuring effects. The recommended treatment protocol depends on the skin condition and desired outcome. Typically, 1–3 sessions are performed, followed by a 3–4 week interval. Maintenance treatments can be scheduled as needed to prolong results. Duration of Effect: Results generally last between 6 and 12 months, depending on skin type, age, lifestyle, and injection technique. After treatment, the skin appears smoother, firmer, and visibly rejuvenated. Packaging Content: 1 pre-filled syringe of 1.5 ml 2 sterile needles (30G x 13 mm) Packaging design may vary. Key Benefits: Bio-revitalizing and skin-restructuring effect Stimulates fibroblast activity to enhance collagen and elastin production Anti-aging effect that prevents wrinkle formation Improves skin elasticity and firmness Provides antioxidant protection and deep hydration Suitable for sensitive skin areas

NucleoFill™ Strong – Bio-Stimulating Gel with Polynucleotides 25 mg/ml NucleoFill™ Strong is a highly concentrated bio-stimulating skin booster based on polymerized polynucleotides (25 mg/ml), developed for deep skin regeneration and contour enhancement of mature, damaged, or stressed skin. It visibly reduces medium to deep wrinkles, smooths scars and stretch marks, and firms the skin on the face and body — ideal for treatment areas such as the abdomen, thighs, buttocks, décolleté, neck, hands, and face. Through fibroblast stimulation, NucleoFill™ Strong promotes the natural production of collagen and elastin, enhancing skin structure, firmness, and long-term elasticity. Composition: Polynucleotides: 25 mg/ml Pre-filled syringe: 1.5 ml Indications: Medium to deep wrinkles Extensive scars and stretch marks Sagging, mature, or damaged skin Face, neck, décolleté, hands, abdomen, thighs, buttocks Intensive hydration and antioxidant protection Application: NucleoFill™ Strong is administered intradermally via mesotherapy to achieve optimal restructuring and lifting effects. The recommended protocol includes 1–2 initial sessions, followed by maintenance treatments after 2–4 weeks, depending on the patient’s skin condition and treatment goals. Duration of Effect: Results typically last 6–12 months, depending on skin type, age, lifestyle, and the number of follow-up sessions. After treatment, the skin appears smoother, firmer, and visibly rejuvenated with improved texture and tone. Packaging Content: 1 pre-filled syringe of 1.5 ml 2 sterile needles (30G x 13 mm) Packaging design may vary. Key Benefits: Deep skin rejuvenation, firming, and contour enhancement Reduces deep wrinkles and scars, visibly reshaping the skin Triple action: collagen stimulation, antioxidant defense, and moisture retention High polynucleotide concentration (25 mg/ml) for maximum efficacy Suitable for sensitive areas such as the neck, hands, or intimate region Safety Information: CE-certified medical device made in the EU (Italy). For professional use only. Not intended for home use. Administration should only be performed by trained and medically qualified professionals in accordance with local regulations. Product image may vary.

Plinest – Biostimulating Gel for Skin Structure Improvement with Polynucleotides Plinest is an innovative biostimulating gel based on highly purified polynucleotides (PN‑HPT®), specifically formulated to support targeted skin regeneration and structural improvement. Developed in Italy, Plinest utilizes the restorative power of DNA fragments to activate cellular repair processes, enhance skin elasticity, and promote a healthy moisture balance. It is highly effective for treating mature, stressed, or scarred skin—all without hormonal additives. The result is a visibly smoother, firmer, and more radiant complexion. Composition Polynucleotides (PN‑HPT®): 40 mg/2 ml (equivalent to 20 mg/ml) Indications Plinest is suitable for the treatment of: Skin rejuvenation in cases of elasticity loss Photo‑damaged skin Improvement of acne scars and other scars Restructuring dry or dehydrated skin Optimization of skin texture and firmness Application The product is injected intradermally into the mid to deep dermis. A typical treatment protocol consists of 3 to 4 sessions spaced 2 to 3 weeks apart. Maintenance treatments can be performed every 4 to 6 months, depending on the patient’s skin condition and desired outcome. Duration of Effect Results generally last 6 to 9 months, depending on the individual’s skin condition, lifestyle, and biological response. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½'', 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest Eye – Gentle Skin Revitalization for the Delicate Under‑Eye Area Plinest Eye is a specialized injectable gel designed to regenerate and rejuvenate the sensitive skin around the eyes. Utilizing proven PN‑HPT® technology with highly purified polynucleotides, it stimulates cell renewal, improves skin structure, and provides deep hydration without the use of hormonal or artificial active ingredients. It is ideal for treating fine lines, dark circles, mild puffiness, and overall structural damage in the periorbital region, resulting in a brighter, smoother, and more refreshed appearance. Composition Polynucleotides (PN‑HPT®): 15 mg/2 ml (equivalent to 7.5 mg/ml) Indications Plinest Eye is suitable for: Fine lines and superficial wrinkles Crow’s feet Dark circles and mild under‑eye swelling Upper eyelid skin laxity Structurally damaged skin around the eyes Uneven tone and texture in the periorbital area Application Plinest Eye is injected intradermally in small amounts into the dermis. The recommended initial protocol includes 3 to 4 treatment sessions spaced 2 to 3 weeks apart. Maintenance treatments may be repeated regularly depending on skin condition and patient needs. Its gentle formulation makes it suitable for delicate, thin periorbital skin. Duration of Effect Results typically last 6 to 12 months, varying with skin type, age, lifestyle, and the patient’s natural regenerative capacity. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest Fast – Rapid Skin Regeneration with Highly Purified Polynucleotides Plinest Fast is an innovative injectable gel designed for targeted regeneration and revitalization of damaged skin. Powered by patented PN‑HPT® technology, it delivers highly purified polynucleotides that stimulate cell renewal, improve overall skin structure, and activate natural healing processes. Particularly suitable for treating scars and stretch marks, Plinest Fast offers an effective solution for patients with skin in need of accelerated repair and reinforcement. Composition Polynucleotides (PN‑HPT®): 15 mg/2 ml (equivalent to 7.5 mg/ml) Indications Plinest Fast is suitable for: Stretch marks Acne and surgical scars Structurally damaged skin following aesthetic procedures Fine lines and dehydration wrinkles Mature, sensitive, or dehydrated skin Application Plinest Fast is injected intradermally into the mid‑dermal layer. A recommended initial protocol includes 3 to 4 sessions, spaced 10 to 14 days apart. For maintenance, treatments may be repeated every 4 to 6 weeks. After each session, patients should avoid intense sun exposure, sauna use, steam baths, and physical exercise for at least 24 hours. Duration of Effect Results typically last 4 to 6 months, depending on individual skin type, lifestyle, and overall skin condition. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest Hair – Biological Support for Hair Growth & Scalp Regeneration Plinest Hair is an innovative injectable gel designed to revitalize the scalp and support healthy hair growth. Powered by patented PN‑HPT® technology, it delivers highly purified polynucleotides that activate cellular regeneration, improve microcirculation, and strengthen the environment surrounding hair follicles. Suitable for both men and women with sensitive or weakened scalp conditions, Plinest Hair can also be used as an adjunct treatment before or after hair transplantation procedures to enhance overall follicular support. Composition Polynucleotides (PN‑HPT®): 15 mg/2 ml (equivalent to 7.5 mg/ml) Indications Plinest Hair is suitable for: Hair loss Weak or compromised hair follicles Scalp revitalization Stimulation of hair growth Enhancing eyebrow density Application Plinest Hair is injected intradermally into the scalp or eyebrow region. A recommended initial treatment cycle consists of 4 to 6 sessions, spaced 7 days apart. For maintenance, treatment may be repeated every 4 to 6 weeks. After application, patients should avoid intense sun exposure, sauna use, steam baths, and vigorous physical activity for 24 hours to ensure optimal results. Duration of Effect Results typically last 6 to 12 months, depending on individual factors such as hair structure, skin type, lifestyle, and overall scalp health. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

Plinest One – Deep‑Acting Skin Revitalization for Large Body Areas Plinest One is an advanced biostimulation gel based on highly purified polynucleotides (PN‑HPT®), specifically developed for the treatment and restructuring of large skin areas. The formulation visibly improves firmness, elasticity, and overall skin texture, making it ideal for patients experiencing skin laxity, stretch marks, or age‑related structural deterioration on the abdomen, buttocks, thighs, arms, and décolletage. Composition Polynucleotides (PN‑HPT®): 2 mg/ml Indications Plinest One is suitable for improving: Skin laxity on arms, thighs, abdomen, and buttocks Loss of elasticity in the décolletage Visible stretch marks (e.g., post‑pregnancy or after weight loss) Skin texture, firmness, and hydration Application Plinest One is injected intradermally into the mid dermal layer. For optimal results, the manufacturer recommends a treatment course of 3 to 6 sessions, spaced 2 to 4 weeks apart. As an alternative to injection, it may also be applied using non‑invasive methods such as iontophoresis, electroporation, or hydroelectrophoresis, depending on practitioner preference and patient suitability. Duration of Effect Results typically last 6 to 12 months, depending on individual skin condition, lifestyle, and physiological factors. Packaging Content 5 glass ampoules × 4 ml No needles included (manufacturer recommends 30G) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

PolyPhil 1×2 ml – Skin‑Rejuvenating & Hydrating Polynucleotide Serum PolyPhil 1×2 ml is an advanced, rejuvenating polynucleotide serum designed to improve skin firmness, elasticity, hydration, and overall quality. Formulated with highly purified polynucleotides at a concentration of 20 mg/ml (40 mg per syringe), this injectable treatment supports cellular regeneration, enhances dermal structure, and promotes a fresher, smoother complexion. Suitable for normal, sensitive, and mature skin, PolyPhil is ideal for revitalizing multiple facial and body areas as well as treating scars and acne scars. Composition Polynucleotides: 20 mg/ml (40 mg total per 2 ml syringe) Indications PolyPhil 1×2 ml is suitable for: Face (including forehead, brow area, periorbital region, cheekbones) Neck Décolletage Hands Scars and acne scars Normal, sensitive, and mature skin Application PolyPhil 1×2 ml is injected intradermally into the dermis. Recommended treatment protocols: Normal skin: 3 sessions, each 14–21 days apart, using 2 ml per session Mature skin: 4 sessions, same intervals Scar treatment: 2 sessions, spaced 3 weeks apart The product can be applied to the entire face, neck, décolletage, and hands. Common treatment regions include the forehead, cheeks, chin, and nose. The therapy promotes firmer, more elastic, and visibly refreshed skin with progressive improvement over the treatment course. Duration of Effect Results become visible after only a few sessions. Skin appears firmer, more elastic, and more radiant. Scars typically brighten significantly within two sessions. The effects last several months, depending on skin type and treatment protocol. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained, medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

PolyPhil Eye 1×2 ml – Serum for Revitalizing the Eye Area PolyPhil Eye 1×2 ml is an advanced polynucleotide-based serum specifically formulated to rejuvenate and firm the delicate skin around the eyes. With a concentration of 7.5 mg/ml (15 mg per syringe) of highly purified polynucleotides, it enhances cellular repair, improves microcirculation, and restores hydration. The treatment softens fine lines, brightens dark circles, and improves the appearance of drooping eyelids. Suitable for sensitive and reactive skin, PolyPhil Eye offers both corrective and preventive benefits for a refreshed, awakened look. Composition Polynucleotides: 7.5 mg/ml (15 mg total per 2 ml syringe) Indications PolyPhil Eye is suitable for revitalizing: Eye contour Eyelids Brow area Crow’s feet Drooping eyelids Scars around the eye area Sensitive and delicate skin Application PolyPhil Eye 1×2 ml is injected intradermally into the dermis. The recommended dose is 1–2 ml per session. The manufacturer advises 3 to 4 treatment sessions, spaced 14 to 21 days apart. This serum effectively targets dark circles, fine lines, puffiness, loss of firmness, and structural fatigue in the periorbital region. It can be used preventively on young skin or to improve the quality and resilience of mature skin. Additionally, PolyPhil Eye is suitable as a preparatory treatment before procedures such as laser therapy, fillers, peels, microneedling, radiofrequency, or surgical interventions. Duration of Effect Visible improvements—such as brighter, smoother, and more refreshed skin—typically appear after just a few sessions. Results are long‑lasting and contribute to sustained enhancement of skin texture and tone. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained, medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

PolyPhil Hair 1×2 ml – Serum for Hair Growth Stimulation PolyPhil Hair 1×2 ml is an advanced injectable serum formulated to stimulate hair growth and revitalize the scalp. With highly purified polynucleotides (PN) at a concentration of 7.5 mg/ml (15 mg per syringe), this treatment enhances cellular regeneration, strengthens hair follicles, and supports healthier, denser, and more resilient hair. It is suitable for women experiencing hormonally induced hair loss and is particularly well‑tolerated by sensitive or easily irritated skin. In addition to scalp use, PolyPhil Hair can also promote eyebrow growth and may complement other therapeutic approaches. Composition Polynucleotides: 7.5 mg/ml (15 mg total per 2 ml syringe) Indications PolyPhil Hair 1×2 ml is suitable for: Scalp treatments Eyebrow enhancement Women with hormonally induced hair loss Sensitive or easily irritated skin Application PolyPhil Hair 1×2 ml is injected intradermally into the dermis. The recommended dosage is 2 ml per session. The treatment protocol consists of two phases: Phase 1: Four sessions, spaced 7 to 14 days apart Phase 2: One session every 21 days, for a total of four additional sessions The serum is suitable as a standalone therapy or as a complementary treatment alongside biotin, hyaluronic acid, carboxytherapy, and topical therapies. It is also appropriate for use following hair transplantation to support follicular recovery and optimize results. Duration of Effect Visible improvement can be observed after just a few sessions. Hair becomes stronger, denser, and healthier. Results typically last several months up to over a year, depending on individual hair type, scalp condition, and lifestyle factors. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.

PolyPhil Next 1×2 ml – Serum for Intensive Skin Rejuvenation & Deep Hydration PolyPhil Next 1×2 ml is an advanced injectable serum designed to deeply rejuvenate the skin and restore optimal hydration levels. Combining highly purified polynucleotides (10 mg/ml), non‑crosslinked hyaluronic acid (10 mg/ml), and mannitol (36.5 mg/ml), this synergistic formula enhances cellular repair, improves dermal structure, and delivers long‑lasting moisture. It is ideal for treating mature, dehydrated, or structurally compromised skin, as well as scars, acne scars, and stretch marks. PolyPhil Next revitalizes the complexion, smooths fine irregularities, and restores elasticity for a fresher, firmer appearance. Composition Polynucleotides: 10 mg/ml (20 mg per 2 ml syringe) Non‑crosslinked hyaluronic acid: 10 mg/ml (20 mg per 2 ml syringe) Mannitol: 36.5 mg/ml Indications PolyPhil Next 1×2 ml is suitable for: Mature and dehydrated skin Face (including tear troughs, cheeks, forehead, chin) Neck and décolletage Hands Scars and acne scars Stretch marks Application PolyPhil Next is injected intradermally into the dermis. Recommended dosage is 2 ml per session. Treatment protocol: Normal skin: 3 sessions, spaced 14–21 days apart Advanced skin aging: 4 sessions, same interval The serum may be used alone or as a preparatory step before aesthetic treatments such as fillers, laser procedures, radiofrequency, peels, microneedling, or surgery. It improves skin texture, provides deep hydration, and helps remodel sunken scars and stretch marks for a smoother and more uniform appearance. Duration of Effect Visible improvements—including smoother, more elastic, and fresher‑looking skin—appear after just a few sessions. Results last several months, depending on skin type and treatment protocol. Packaging Content 1 pre‑filled syringe × 2 ml 2 sterile needles (30G × ½", 13 mm) Additional Information This product is intended exclusively for use by trained and medically qualified professionals in accordance with local regulations. Product image may vary from the actual packaging.